Paired whole genome sequencing for children with suspected cancer

Dr Sarah Leiter, Cambridge University Hospitals NHS Foundation Trust, provides insights into the implementation of paired whole genome sequencing (WGS) for children with suspected cancer. The discussion highlights how routine WGS can be delivered as part of clinical care, offering significant benefits by rapidly identifying genetic changes that inform diagnosis and treatment decisions. Dr Leiter emphasises the importance of this approach in improving outcomes for children with suspected cancer, enabling more precise and individualized management strategies. She outlines how integrating WGS into routine clinical pathways can change clinical management and support families facing complex diagnostic journeys. This interview took place at the RCPCH conference 2025 in Glasgow, Scotland.